Anti-GLP-1(9-37) and GLP-1(9-36)amide (N-terminal specific)

ABS 044-49

ABS 044-49 binds human GLP-1(9-36)amide. Based on inhibition ELISA, ABS 044-49 cross-reacts 3% with GLP-1(7-36)amide.

Synthetic GLP-1(9-18)

Mouse

Mammalia

Not determined

IgG1/k

2641

49

The free N-terminus of GLP-1(9-36)amide and GLP-1(9-37).

400 µL: Cat. No. ABS 044-49-04 1 mL: Cat. No. ABS 044-49-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Protein A/G purified (from culture supernatant)

Liquid

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Unconjugated BSA free

4-8ºC without exposure to light. No precautions necessary during handling.

Glucagon-like peptide-1(9-36)amide and GLP-1(9-37) are the forms of GLP-1 that result from the rapid degradation of the active forms of the peptide (GLP-1(7-36)amide and GLP-1(7-37)) by the enzyme dipeptidyl peptidase-IV (DPP-IV, also known as CD26 or adenosine deaminase binding protein). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.