Mouse monoclonal antibody

Anti-GLP-1(9-37) and GLP-1(9-36)amide (N-terminal specific)

CAT NO: ABS 044-49 | Application: ELISA, WB

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Product Summary

Cat. No.
ABS 044-49
Specificity
ABS 044-49 binds human GLP-1(9-36)amide. Based on inhibition ELISA, ABS 044-49 cross-reacts 3% with GLP-1(7-36)amide.
Immunogen
Synthetic GLP-1(9-18)
Host
Mouse
Positive Species Reactivity
Mammalia
Negative Species Reactivity
Not determined
Isotype
IgG1/k
Gene ID
2641
Clone Number
49
Epitope Specificity
The free N-terminus of GLP-1(9-36)amide and GLP-1(9-37).
Unit Size
400 µL: Cat. No. ABS 044-49-04 1 mL: Cat. No. ABS 044-49-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Glucagon-like peptide-1(9-36)amide and GLP-1(9-37) are the forms of GLP-1 that result from the rapid degradation of the active forms of the peptide (GLP-1(7-36)amide and GLP-1(7-37)) by the enzyme dipeptidyl peptidase-IV (DPP-IV, also known as CD26 or adenosine deaminase binding protein). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

Application

ELISA: ABS 044-49 binds free GLP-1(9-36)amide in solution. In a sandwich ELISA ABS 044-49 (as capture antibody) forms a pair with HYB 147-06B (as biotinylated detection antibody) in order to measure ”degraded GLP-1” (the GLP-1 metabolite (GLP-1(9-36)amide)).

WB: ABS 044-49 can be used in Western blotting.

Cat. No.
ABS 044-49
Specificity
ABS 044-49 binds human GLP-1(9-36)amide. Based on inhibition ELISA, ABS 044-49 cross-reacts 3% with GLP-1(7-36)amide.
Immunogen
Synthetic GLP-1(9-18)
Host
Mouse
Positive Species Reactivity
Mammalia
Negative Species Reactivity
Not determined
Isotype
IgG1/k
Gene ID
2641
Clone Number
49
Epitope Specificity
The free N-terminus of GLP-1(9-36)amide and GLP-1(9-37).
Unit Size
400 µL: Cat. No. ABS 044-49-04 1 mL: Cat. No. ABS 044-49-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Glucagon-like peptide-1(9-36)amide and GLP-1(9-37) are the forms of GLP-1 that result from the rapid degradation of the active forms of the peptide (GLP-1(7-36)amide and GLP-1(7-37)) by the enzyme dipeptidyl peptidase-IV (DPP-IV, also known as CD26 or adenosine deaminase binding protein). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

ELISA: ABS 044-49 binds free GLP-1(9-36)amide in solution. In a sandwich ELISA ABS 044-49 (as capture antibody) forms a pair with HYB 147-06B (as biotinylated detection antibody) in order to measure ”degraded GLP-1” (the GLP-1 metabolite (GLP-1(9-36)amide)).

WB: ABS 044-49 can be used in Western blotting.

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Product Specification

Non-hazardous statement (SDS)

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