Mouse monoclonal antibody
Anti-Pregnancy associated plasma protein A (human, PAPP-A)
CAT NO: ABS 006-24 | Application: ELISA, WB, IHC
Cat. No. |
ABS 006-24 |
---|---|
Specificity |
ABS 006-24 is specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. |
Immunogen |
Purified human PAPP-A |
Host |
Mouse |
Positive Species Reactivity |
Human |
Negative Species Reactivity |
Not determined |
Isotype |
IgG1/k |
Gene ID |
5069 |
Clone Number |
PAPP A 1-24 |
Epitope Specificity |
The epitope of ABS 006-24 is different from BTE 004-09 and ABS 006-01. The epitope is located on the PAPP-A subunit of the heterotetramer. |
Unit Size |
400 µL: Cat. No. ABS 006-24-04 1 mL: Cat. No. ABS 006-24-1 1 mg/mL +/- 15%. See Certificate of Analysis for details. |
Purification |
Protein A/G purified (from culture supernatant) |
Form |
Liquid |
Solvent |
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide |
Conjugation |
Unconjugated BSA free |
Storage |
4-8ºC without exposure to light. No precautions necessary during handling. |
Target |
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21). |