Product Summary

Cat. No.
HYB 238-04B
Specificity
HYB 238-04 is specific for human pulmonary Surfactant protein A (SP-A).
Immunogen
Native SP-A purified from bronchioaveolar lavage from proteinosis patients
Host
Mouse
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Isotype
IgG1/k
Gene ID
653509
Clone Number
6F10
Epitope Specificity
Not determined
Unit Size
150 µL: Cat. No. HYB 238-04B-015 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Biotinylated
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15mM sodium azide
Conjugation
Biotin
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/ml in healthy individuals.

Application

ELISA: HYB 238-04 can be used in ELISA.

Cat. No.
HYB 238-04B
Specificity
HYB 238-04 is specific for human pulmonary Surfactant protein A (SP-A).
Immunogen
Native SP-A purified from bronchioaveolar lavage from proteinosis patients
Host
Mouse
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Isotype
IgG1/k
Gene ID
653509
Clone Number
6F10
Epitope Specificity
Not determined
Unit Size
150 µL: Cat. No. HYB 238-04B-015 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Biotinylated
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15mM sodium azide
Conjugation
Biotin
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/ml in healthy individuals.

ELISA: HYB 238-04 can be used in ELISA.

×