Mouse monoclonal antibody

Anti-Complement component C1s, (human, pro- and activated enzyme)

CAT NO: ABS 002-49 | Application: ELISA, IF

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Cat. No.	ABS 002-49
Specificity	ABS 002-49 is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor.
Immunogen	Human plasma C1s Proenzyme
Host	Mouse
Positive Species Reactivity	Human
Negative Species Reactivity	Not determined
Isotype	IgG1/k
Gene ID	716
Clone Number	49
Epitope Specificity	Epitope differs from that of ABS 002-09.
Unit Size	400 µL: Cat. No. ABS 002-09-04 1 mL: Cat. No. ABS 002-09-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification	Protein-A/G purified, from culture supernatant
Form	Liquid
Solvent	0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation	Unconjugated BSA free
Storage	4-8ºC without exposure to light. No precautions necessary during handling.
Target	C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.