The NGAL TestTM
A tool for risk assessment of kidney damage that
can help you get ahead of the creatinine clock
Talk with Us about NGAL
The NGAL Test*
Until now, assessing risk of AKI in critically ill patients has relied on changes in serum creatinine and urine output, physiologic endpoints that are delayed, non-specific, and impacted by extrarenal factors such as nutritional status and muscle mass.
The NGAL Test is designed to help clinicians identify levels of urinary or plasma NGAL, a biomarker that rises rapidly in response to kidney injury, preceding changes in creatinine by as much as 2 to 3 days.i
By identifying patients at risk of AKI early, clinicians can take more appropriate action to manage fluid levels, avoid nephrotoxic agents, and potentially prevent permanent, kidney damage.i
*The NGAL Test is CE marked and available for in vitro diagnostic use in the European Union, Canada, Korea and Israel, and for Research Use Only in all other regions.
Benefits of NGAL
NGAL responds just 2 hours after kidney injuryii and 2-3 days before serum creatinine rises.i
NGAL+ identifies subclinical AKI when serum creatinine alone failed to identify 43% of AKI.iii
Identifies patients at risk of developing moderate to severe AKI.iv
Improved management of AKI can reduce LOS, minimize unnecessary interventions, and inform treatment choices.
The NGAL biomarker has been studied in over 16,500 patients in numerous settings including post-cardiac surgery, in critical illness, and post kidney transplantation. In each setting, “NGAL significantly improved the prediction of AKI risk over the clinical model alone.” v
Identification of AKI Risk
The NGAL biomarker has been shown to offer early clinical decision support to guide patient management.
Adapted from: Murray PT, Mehta RL, Shaw A, et al. Potential use of biomarkers in acute kidney injury report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney Int. 2014.85(3):513-521 and Stanski N, Menon S, Goldstein SL, Basu RJ. Integration of urinary neutrophil gelatinase-associated lipocalin with serum creatinine delineates acute kidney injury phenotypes in critically ill children. Journal Critical Care. 2019.53:1-7.
i Devarajan P. Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury. Biomark Med. 2010;4(2):265–280.
ii Krawczeski CD, Goldstein SL, Woo JG, et al. Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass. J Am Coll Cardiol. 2011;58(22):2301–2309.
iii Haase M, Devarajan P, Haase-Fielitz A, et al. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol. 2011;57(17):1752–1761.
iv Zappitelli M, Washburn KK, Arikan AA, et al. Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care. 2007;11(4):R84.
v Haase-Fielitz A, Haase M, Devarajan P. Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status. Ann Clin Biochem. 2014;51(Pt 3):335–351.