Anti-Gelsolin (human)

CAT NO: ABS 017-20

Request Price

"*" indicates required fields

Comments

This field is for validation purposes and should be left unchanged.

Name*

First Last

Email*

Phone

Organization

Shipping Address*

City, State, Post Code/Zip*

Country*

States*

Catalog Number ( Product )

Message

ELISA	ABS 017-20 does not work as a capture antibody in sandwich ELISA.
WB	ABS 017-20 can be used in Western blotting.
IHC	ABS 017-20 can be used in Immunohistochemistry.
	Immunohistochemical staining of human kidney with ABS 017-20 shows cytoplasmic and membranous positivity in both renal tubules and glomeruli. Antibody dilution: 1:6000 (www.proteinatlas.org)
IF	ABS 017-20 can be used in Immunofluorescence.
	Immunofluorescent staining of human cell line U-251 MG shows positivity in actin filaments. Antibody dilution: 1:2000 (www.proteinatlas.org)

Specificity
Specificity	ABS 017-20 binds human gelsolin.
Immunogen	Gelsolin purified from human plasma
Target	Gelsolin participates in the extracellular actin scavenger system, binding actin and disaggregating filamentous actin released from dying cells. Actin monomers are then transferred to Gc-globulin. The plasma concentration of gelsolin is reduced in conditions of major actin release, such as acute liver failure, major trauma and rhabdomyolysis, where multi-organ failure is a risk. It has been suggested that gelsolin, like Gc-globulin, can be a prognostic factor in these conditions.
Gene ID	2934
Species Reactivity POSITIVE	Human
Species Reactivity NEGATIVE	Not determined

Properties
Form	Liquid
Unit Size	0,4 mL and 1 mL
Concentration	1 mg/mL ±15%, See CoA for lot details
Purification	Protein A or Protein G purified
Purification Notes	BSA free
Storage buffer	0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide