Product Summary

Cat. No.
DIA 011-01B
Specificity
DIA 011-01 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive). (1)
Immunogen
Purified C5b-9
Host
Mouse
Positive Species Reactivity
Human, Pig, Horse, Baboon
Negative Species Reactivity
Not determined
Isotype
IgG2a/k
Gene ID
727
Clone Number
aE11
Epitope Specificity
DIA 011-01 binds to a neoepitope exposed on C9
Unit Size
150 μL, 1 mg/mL +/- 15%. Cat. No. DIA 011-01B-015 See Certificate of Analysis for details.
Purification
Biotinylated
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.15 M NaCl, 15mM NaN3
Conjugation
Biotin
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
C5b-9 is also known as the terminal complement complex (TCC). The TCC consists of C5b, C6, C7, C8 and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual native components from which they are formed and DIA 011-01 is directed against a neoepitope exposed on C9 when incorporated into the TCC.
Other Info
This product is not for further manaufacture.

Application

ELISA: DIA 011-01 can be used in ELISA.

Scientific References

1. Mollnes TE, Harboe M (1987) Immunohistochemical detection of the membrane and fluid-phase terminal complement complexes C5b-9(m) and SC5b-9. Consequences for interpretation and terminology. Scand J Immunol 26:381-6

Cat. No.
DIA 011-01B
Specificity
DIA 011-01 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive). (1)
Immunogen
Purified C5b-9
Host
Mouse
Positive Species Reactivity
Human, Pig, Horse, Baboon
Negative Species Reactivity
Not determined
Isotype
IgG2a/k
Gene ID
727
Clone Number
aE11
Epitope Specificity
DIA 011-01 binds to a neoepitope exposed on C9
Unit Size
150 μL, 1 mg/mL +/- 15%. Cat. No. DIA 011-01B-015 See Certificate of Analysis for details.
Purification
Biotinylated
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.15 M NaCl, 15mM NaN3
Conjugation
Biotin
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
C5b-9 is also known as the terminal complement complex (TCC). The TCC consists of C5b, C6, C7, C8 and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual native components from which they are formed and DIA 011-01 is directed against a neoepitope exposed on C9 when incorporated into the TCC.
Other Info
This product is not for further manaufacture.

ELISA: DIA 011-01 can be used in ELISA.

1. Mollnes TE, Harboe M (1987) Immunohistochemical detection of the membrane and fluid-phase terminal complement complexes C5b-9(m) and SC5b-9. Consequences for interpretation and terminology. Scand J Immunol 26:381-6

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