Mouse monoclonal antibody
Anti-Fibronectin (bovine, human, chicken)
CAT NO: CSI 005-17 | Application: ELISA, WB, IHC-F, IHC-P, IP
Cat. No. |
CSI 005-17 |
|---|---|
Specificity |
CSI 005-17 is highly specific for fibronectin. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, elastin, collagen, laminin). The antibody inhibits integrin-mediated cell adhesion to the cell binding domain of fibronectin. |
Immunogen |
Lysed bovine corneal endothelial cells and extracellular matrix |
Host |
Mouse |
Positive Species Reactivity |
Bovine, Human, Chicken |
Negative Species Reactivity |
Not determined |
Isotype |
IgG1/k |
Gene ID |
280794 (2335, 396133) |
Clone Number |
A17 |
Epitope Specificity |
Epitope is located in the 120kD cell binding fragment |
Unit Size |
400 µL: Cat. No. CSI 005-17-04 1 mL: Cat. No. CSI 005-17-1 1 mg/mL +/- 15%. See Certificate of Analysis for details. |
Purification |
Protein A/G purified (from culture supernatant) |
Form |
Liquid |
Solvent |
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide |
Conjugation |
Unconjugated BSA free |
Storage |
4-8ºC without exposure to light. No precautions necessary during handling. |
Target |
Fibronectin is an adhesive glycoprotein with a molecular mass of 440 kDa. It is believed to be important for the formation of a provisional matrix that promotes cell adhesion and migration during wound healing. Its age-dependent increase in plasma and tissues may be accompanied in pathological states, especially in tumor growth, by its proteolytic breakdown by a number of neutral proteases. It has also shown that several of its proteolytic breakdown products exhibit unexpected and mostly harmful biological activities. (1) |