Anti-Complement component C1s, (human, pro- and activated enzyme)

CAT NO: ABS 002-09

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Product Name	Anti-Complement component C1s, (human, pro- and activated enzyme)
Description	Mouse monoclonal antibody
Isotype	IgG1/k
Host	Mouse
Clone	9
Conjugation	Unconjugated
Tested Applications	ELISA, IHC

ELISA	ABS 002-09 reacts in ELISA when tested with activated C1s enzyme directly coated onto the microtiter well or in sandwich ELISA in combination with a polyclonal antibody in coat.
IHC	ABS 002-09 was used in immunohistochemistry.
	Plasma shows distinct positivity stained with ABS 002-09 on normal rectum tissue.

Specificity
Specificity	ABS 002-09 is specific for C1s proenzyme and activated free C1s.Epitope differs from that of ABS 002-49.
Immunogen	C1s proenzyme purified from human plasma
Target	C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.
Gene ID	716
Species Reactivity POSITIVE	Human
Species Reactivity NEGATIVE	Not determined

Properties
Form	Liquid
Unit Size	0,4 mL and 1 mL
Concentration	1 mg/mL ±15%, See CoA for lot details
Purification	Protein A or Protein G purified
Purification Notes	BSA free
Storage buffer	0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide