| Specificity |
ABS 002-49 is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor.Epitope differs from that of ABS 002-09. |
| Immunogen |
Human plasma C1s Proenzyme |
| Target |
C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2. |
| Gene ID |
716 |
| Species Reactivity POSITIVE |
Human |
| Species Reactivity NEGATIVE |
Not determined |
