Mouse monoclonal antibody

Anti-Complement Component C3 (human)

CAT NO: CAM 008-01 | Application: ELISA, Immunoprecipitation (IP), Immunoaffinity Purification (IAP)

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Product Summary

Cat. No.
CAM 008-01
Specificity
CAM 008-01 is specific for human complement component 3 (C3/C3b/C3c).
Immunogen
Complement component 3 (C3) purified from human plasma.
Host
Mouse
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Isotype
IgG1/k
Clone Number
F1-8
Epitope Specificity
The antibody CAM 008-01 reacts with the 75 kd beta-chain of the human complement factor 3.
Unit Size
400 µL: Cat. No. CAM 008-01-04 1 mL: Cat. No. CAM 008-01-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
protein A/G purified (from culture supernatant)
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
C3 is a central component of the complement system, consisting of a beta-chain (75 kDa) and an alpha-chain (110 kDa) connected by cystein bridges. Cleavage of C3 into C3b (177 kDa) and C3a (9 kDa) is a pivotal step in the complement activation cascade, which can be initiated by three distinct pathways—the classical, the lectin and the alternative complement pathway.

Application

ELISA: CAM 008-01 was used in ELISA. (1)

Immunoprecipitation (IP): CAM 008-01 was used in IP. (1)

Immunoaffinity Purification (IAP): CAM 008-01 was used in IAP. (1)

Scientific References

1. Palarasah Y, Skjodt K, Brandt J, Teisner B, Koch C, Vitved L, SkjoedtMO: Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3. J Immunol Methods 362:142-150, 2010

Cat. No.
CAM 008-01
Specificity
CAM 008-01 is specific for human complement component 3 (C3/C3b/C3c).
Immunogen
Complement component 3 (C3) purified from human plasma.
Host
Mouse
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Isotype
IgG1/k
Clone Number
F1-8
Epitope Specificity
The antibody CAM 008-01 reacts with the 75 kd beta-chain of the human complement factor 3.
Unit Size
400 µL: Cat. No. CAM 008-01-04 1 mL: Cat. No. CAM 008-01-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
protein A/G purified (from culture supernatant)
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
C3 is a central component of the complement system, consisting of a beta-chain (75 kDa) and an alpha-chain (110 kDa) connected by cystein bridges. Cleavage of C3 into C3b (177 kDa) and C3a (9 kDa) is a pivotal step in the complement activation cascade, which can be initiated by three distinct pathways—the classical, the lectin and the alternative complement pathway.

ELISA: CAM 008-01 was used in ELISA. (1)

Immunoprecipitation (IP): CAM 008-01 was used in IP. (1)

Immunoaffinity Purification (IAP): CAM 008-01 was used in IAP. (1)

1. Palarasah Y, Skjodt K, Brandt J, Teisner B, Koch C, Vitved L, SkjoedtMO: Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3. J Immunol Methods 362:142-150, 2010

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