Anti-Complement component C5b-9 (human)

CAT NO: DIA 011-01B

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Product Name	Anti-Complement component C5b-9 (human)
Description	Mouse monoclonal antibody, biotinylated
Isotype	IgG2a/k
Host	Mouse
Clone	aE11
Conjugation	Biotin
Tested Applications	ELISA

Specificity
Specificity	DIA 011-01 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive). (1)DIA 011-01 binds to a neoepitope exposed on C9
Immunogen	Purified C5b-9
Target	C5b-9 is also known as the terminal complement complex (TCC). The TCC consists of C5b, C6, C7, C8 and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual native components from which they are formed and DIA 011-01 is directed against a neoepitope exposed on C9 when incorporated into the TCC.
Gene ID	727
Species Reactivity POSITIVE	Human, Pig, Horse, Baboon
Species Reactivity NEGATIVE	Not determined

Properties
Form	Liquid
Unit Size	0,15 mL
Concentration	1 mg/mL ±15%, See CoA for lot details
Purification	Protein A or Protein G purified
Purification Notes	BSA free
Storage buffer	0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide