Mouse monoclonal antibody, biotinylated

Anti-Complement component C5b-9 (human)

CAT NO: DIA 011-01B | Application: ELISA

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Cat. No.	DIA 011-01B
Specificity	DIA 011-01 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive). (1)
Immunogen	Purified C5b-9
Host	Mouse
Positive Species Reactivity	Human, Pig, Horse, Baboon
Negative Species Reactivity	Not determined
Isotype	IgG2a/k
Gene ID	727
Clone Number	aE11
Epitope Specificity	DIA 011-01 binds to a neoepitope exposed on C9
Unit Size	150 μL, 1 mg/mL +/- 15%. Cat. No. DIA 011-01B-015 See Certificate of Analysis for details.
Purification	Biotinylated
Form	Liquid
Solvent	0.01 M phosphate buffer, pH 7.4, containing 0.15 M NaCl, 15mM NaN3
Conjugation	Biotin
Storage	4-8ºC without exposure to light. No precautions necessary during handling.
Target	C5b-9 is also known as the terminal complement complex (TCC). The TCC consists of C5b, C6, C7, C8 and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual native components from which they are formed and DIA 011-01 is directed against a neoepitope exposed on C9 when incorporated into the TCC.
Other Info	This product is not for further manaufacture.