Mouse monoclonal antibody

Anti-Gelsolin (human)

CAT NO: ABS 017-20 | Application: ELISA, WB, IHC, IF

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Cat. No.	ABS 017-20
Specificity	ABS 017-20 binds human gelsolin.
Immunogen	Gelsolin purified from human plasma
Host	Mouse
Positive Species Reactivity	Human
Negative Species Reactivity	Not determined
Isotype	IgG1/k
Gene ID	2934
Clone Number	20
Epitope Specificity	Not determined
Unit Size	400 µL: Cat. No. ABS 017-20-04 1 mL: Cat. No. ABS 017-20-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification	Protein A/G purified (from culture supernatant)
Form	Liquid
Solvent	0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation	Unconjugated BSA free
Storage	4-8ºC without exposure to light. No precautions necessary during handling.
Target	Gelsolin participates in the extracellular actin scavenger system, binding actin and disaggregating filamentous actin released from dying cells. Actin monomers are then transferred to Gc-globulin. The plasma concentration of gelsolin is reduced in conditions of major actin release, such as acute liver failure, major trauma and rhabdomyolysis, where multi-organ failure is a risk. It has been suggested that gelsolin, like Gc-globulin, can be a prognostic factor in these conditions.