| Specificity |
ABS 006-01 is specific for native human PAPP-A.The epitope of ABS 006-01 is different from BTE 004-09 and ABS 006-24. The epitope is located on the PAPP-A subunit of the heterotetramer. |
| Immunogen |
Purified human PAPP-A |
| Target |
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21). |
| Gene ID |
5069 |
| Species Reactivity POSITIVE |
Human |
| Species Reactivity NEGATIVE |
Not determined |
