Mouse monoclonal antibody

Anti-Pregnancy associated plasma protein A (human, PAPP-A)

CAT NO: ABS 006-01 | Application: ELISA, WB, IHC

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Cat. No.	ABS 006-01
Specificity	ABS 006-01 is specific for native human PAPP-A.
Immunogen	Purified human PAPP-A
Host	Mouse
Positive Species Reactivity	Human
Negative Species Reactivity	Not determined
Isotype	IgG1/k
Gene ID	5069
Clone Number	PAPP A 1-1
Epitope Specificity	The epitope of ABS 006-01 is different from BTE 004-09 and ABS 001-24. The epitope is located on the PAPP-A subunit of the heterotetramer.
Unit Size	400 µL - Cat. No. ABS 006-01-04 1 mL - Cat. No. ABS 006-01-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification	Protein A/G purified (from culture supernatant)
Form	Liquid
Solvent	0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation	Unconjugated BSA free
Storage	4-8ºC without exposure to light. No precautions necessary during handling.
Target	Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).