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Anti-Fibronectin (bovine, human, chicken)

CAT NO: CSI 005-17

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Product Name	Anti-Fibronectin (bovine, human, chicken)
Description	Mouse monoclonal antibody
Isotype	IgG1/k
Host	Mouse
Clone	A17
Conjugation	Unconjugated
Tested Applications	ELISA, WB, IHC, IP

Specificity
Specificity	CSI 005-17 is highly specific for fibronectin. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, elastin, collagen, laminin). The antibody inhibits integrin-mediated cell adhesion to the cell binding domain of fibronectin.Epitope is located in the 120kD cell binding fragment
Immunogen	Lysed bovine corneal endothelial cells and extracellular matrix
Target	Fibronectin is an adhesive glycoprotein with a molecular mass of 440 kDa. It is believed to be important for the formation of a provisional matrix that promotes cell adhesion and migration during wound healing. Its age-dependent increase in plasma and tissues may be accompanied in pathological states, especially in tumor growth, by its proteolytic breakdown by a number of neutral proteases. It has also shown that several of its proteolytic breakdown products exhibit unexpected and mostly harmful biological activities. (1)
Gene ID	280794, 2335, 396133
Species Reactivity POSITIVE	Bovine, Human, Chicken
Species Reactivity NEGATIVE	Not determined

Properties
Form	Liquid
Unit Size	0,4 mL and 1 mL
Concentration	1 mg/mL ±15%, See CoA for lot details
Purification	Protein A or Protein G purified
Purification Notes	BSA free
Storage buffer	0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide