Anti-GLP-1(7-37) and GLP-1(7-36) amide (N-terminal specific)

CAT NO: ABS 033-04

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Product Name	Anti-GLP-1(7-37) and GLP-1(7-36) amide (N-terminal specific)
Description	Mouse monoclonal antibody
Isotype	IgG1/k
Host	Mouse
Clone	4
Conjugation	Unconjugated
Tested Applications	ELISA, IHC

ELISA	ABS 033-04 binds free GLP-1(7-37) and free GLP-1(7-36) amide. Not recommended for use in sandwich ELISA. (1)
IHC	ABS 033-04 can be used in IHC.
	Endocrine alpha cells from diabetic mice stained with ABS 033-04 (1:500). Courtesy of Dr. Annette Plesner, University of British Columbia.

Specificity
Specificity	ABS 033-04 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity with GLP-1(1-37), GLP-1(9-36)amide, glucagon, human GIP and exendin-4. Cross-reacts approximately 1% with human GLP-2.
Immunogen	Synthetic GLP-1(7-17)
Target	Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
Gene ID	2641
Species Reactivity POSITIVE	Human
Species Reactivity NEGATIVE	Not determined

Properties
Form	Liquid
Unit Size	0,4 mL and 1 mL
Concentration	1 mg/mL ±15%, See CoA for lot details
Purification	Protein A or Protein G purified
Purification Notes	BSA free
Storage buffer	0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide