Anti-Vitronectin (bovine, horse, rabbit)

CSI 004-18

CSI 004-18 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). The antibody inhibits integrin-mediated cell adhesion to bovine vitronectin. It can be used to probe vitronectin conformation.

Lysed bovine corneal endothelial cells and extracellular matrix

Mouse

Bovine, Rabbit, Horse

Human, Sheep

IgG1/k

507525, 100009128, 100059034

A18

Not determined

400 µL: Cat. No. CSI-004-18-04 1 mL: Cat. No. CSI-004-18-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Protein A/G purified (from culture supernatant)

Liquid

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Unconjugated BSA free

4-8ºC without exposure to light. No precautions necessary during handling.

Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognizes fibronectin.