Recombinant protein

Recombinant Rat NGAL

CAT NO: SP003RA

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Product Summary

Cat. No.

SP003RA

Purification

This product is purified full length recombinant protein without any tags, produced from E. coli

Production

E. coli

Source

Full length amino acid sequence

Unit Size, Concentration

1 mL, 400 pg/mL +/- 15%

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl, 0.5% BSA; 0.5% Tween 20; 0.0016% Phenol red; 0.1% Proclin 950

Storage

2-8°C

Background

Rat NGAL, so called because it is the ortholog of human neutrophil gelatinase-associated lipocalin (NGAL), is also called lipocalin-2, 25-kDa alpha 2-microglubin-related protein or neurelated lipocalin. It is expressed by neutrophils and various epithelial cells, including cells tubular cells of the kidney. It is involved in physiological processes such as the binding of siderophore iron and tissue growth and regeneration. It is up-regulated in a variety of pathological situations including infection, inflammation, renal injury and certain adenocarcinomas.

Application

ELISA: This antigen is well suited as a standard in NGAL quantifying assays, such as ELISA.

Scientific References

1. Mishra J et al (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14:2534-43.

2. Zhang J et al (2009) NGAL Expression in Kidney of Spontaneously Hypertensive Rats (SHR) Treated with Doxorubicin (DXR) Alone or Combined with Dexrazoxane (DRZ) (Presented at Tox Expo 2009)

3. Adler M et al (2010) Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies. Toxicology Letters 196:1-11.