Anti-Vitronectin (human, dog, cat, goat, horse, bovine)

CAT NO: CSI 003-23

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Product Name	Anti-Vitronectin (human, dog, cat, goat, horse, bovine)
Description	Mouse monoclonal antibody
Isotype	IgG1/k
Host	Mouse
Clone	HV23
Conjugation	Unconjugated
Tested Applications	ELISA, WB

Specificity
Specificity	CSI 003-23 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). CSI 003-23 binds nearly as well to native vitronectin as to denatured. CSI 003-23 is a potent inhibitor of integrin-mediated cell adhesion to vitronectin and a moderate inhibitor of PAI-1 binding.Epitope is located in the somatomedin B domain
Immunogen	Human vitronectin purified from plasma by heparin-affinity chromatography
Target	Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognizes fibronectin. (2)
Gene ID	7448, 101100765, 480621, 100861216, 507525, 100059034
Species Reactivity POSITIVE	Human, Cat (feline), Dog, Goat (caprine), Bovine, Horse
Species Reactivity NEGATIVE	Not determined

Properties
Form	Liquid
Unit Size	0,4 mL and 1 mL
Concentration	1 mg/mL ±15%, See CoA for lot details
Purification	Protein A or Protein G purified
Purification Notes	BSA free
Storage buffer	0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

ELISA	CSI 003-23 also binds to vitronectin in ELISA when vitronectin is coated directly onto the microtiter well. In Western blotting a dilution guideline of 1/50 and 1/200 has proved successful. (1,2)
WB	CSI 003-23 can be used in Western blotting. (1)