| Specificity |
CSI 004-18 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). The antibody inhibits integrin-mediated cell adhesion to bovine vitronectin. It can be used to probe vitronectin conformation. |
| Immunogen |
Lysed bovine corneal endothelial cells and extracellular matrix |
| Target |
Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognizes fibronectin. |
| Gene ID |
507525, 100009128, 100059034 |
| Species Reactivity POSITIVE |
Bovine, Rabbit, Horse |
| Species Reactivity NEGATIVE |
Human, Sheep |
