Mouse monoclonal antibody

Anti-Pregnancy associated plasma protein A (human, PAPP-A)

CAT NO: BTE 004-09 | Application: ELISA, WB, IHC-P, IHC-F

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Cat. No.	BTE 004-09
Specificity	BTE 004-09 is specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A.
Immunogen	Purified human PAPP-A
Host	Mouse
Positive Species Reactivity	Human
Negative Species Reactivity	Not determined
Isotype	IgG2b/k
Gene ID	5069
Clone Number	9
Epitope Specificity	The epitope of BTE 004-09 is different from ABS 006-01 and ABS 006-24. The epitope is located on the PAPP-A subunit of the heterotetramer.
Unit Size	400 µL: Cat. No. BTE 004-09-04 1 mL: Cat. No. BTE 004-09-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification	protein A/G purified (from culture supernatant)
Form	Liquid
Solvent	0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation	Unconjugated BSA free
Storage	4-8ºC without exposure to light. No precautions necessary during handling.
Target	Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).