Mouse monoclonal antibody

Anti-Pregnancy associated plasma protein A (human, PAPP-A)

CAT NO: ABS 006-01 | Application: ELISA, WB, IHC

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Product Summary

Cat. No.

ABS 006-01

Specificity

ABS 006-01 is specific for native human PAPP-A.

Immunogen

Purified human PAPP-A

Host

Mouse

Positive Species Reactivity

Human

Negative Species Reactivity

Not determined

Isotype

IgG1/k

Gene ID

5069

Clone Number

PAPP A 1-1

Epitope Specificity

The epitope of ABS 006-01 is different from BTE 004-09 and ABS 001-24. The epitope is located on the PAPP-A subunit of the heterotetramer.

Unit Size

400 µL - Cat. No. ABS 006-01-04 1 mL - Cat. No. ABS 006-01-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Protein A/G purified (from culture supernatant)

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Conjugation

Unconjugated BSA free

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).

Application

ELISA: In sandwich ELISA with a polyclonal antibody in coat, ABS 006-01 only reacts poorly with PAPP-A in third trimester serum.

WB: ABS 006-01 only detects unreduced PAPP-A in Western blotting.

IHC: ABS 006-01 can be used in IHC. Please consult www.proteinatlas.org

Paraffin-embedded human placenta tissue immunostained with ABS 006-01. (www.proteinatlas.org)

Immunohistochemical staining of a formalin-fixed, paraffin-embedded placental tissue with ABS 006-01.