Anti-Vitronectin (human, dog, cat, goat, horse, bovine)

CSI 003-23

CSI 003-23 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). CSI 003-23 binds nearly as well to native vitronectin as to denatured. CSI 003-23 is a potent inhibitor of integrin-mediated cell adhesion to vitronectin and a moderate inhibitor of PAI-1 binding.

Human vitronectin purified from plasma by heparin-affinity chromatography

Mouse

Human, Cat (feline), Dog, Goat (caprine), Bovine, Horse

Not determined

IgG1/k

7448, 101100765, 480621, 100861216, 507525, 100059034

HV23

Epitope is located in the somatomedin B domain

400 µL: Cat. No. CSI 003-23-04 1 mL: Cat. No. CSI 003-23-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Protein A/G purified (from culture supernatant)

Liquid

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Unconjugated BSA free

4-8ºC without exposure to light. No precautions necessary during handling.

Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognizes fibronectin. (2)