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Mouse monoclonal antibody, biotinylated

Anti-Peptide YY (human, PYY)

CAT NO: ABS 029-01B | Application: ELISA


Cat. No.

ABS 029-01B

Specificity

ABS 029-01 binds human PYY. Cross-reactivity with NPY or PP in solution is <0.1%.

Immunogen

Synthetic human PYY

Host

Mouse

Positive Species Reactivity

Human

Negative Species Reactivity

Not determined

Isotype

IgG1/k

Gene ID

5697

Clone Number

1

Epitope Specificity

Not determined

Unit Size

150 µL: Cat. No. ABS 029-01B-015 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Biotinylated

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15mM sodium azide

Conjugation

Biotin

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

Peptide tyrosine-tyrosine (PYY) amide is a 36 amino acid. PYY is a member of the pancreatic polypeptide (PP) family of peptides (neuropeptide Y (NPY), PYY and PP). While NPY is localized in neurons (both in the central and peripheral nervous system) and PP in the pancreatic islets, PYY is found in both neurons and the gut. PYY is released in response to food intake from the same endocrine cells (L cells) in the intestinal mucosa as the glucagon-like peptides and inhibits gall bladder secretion, gut motility, and pancreatic secretion. These effects are similar to those of PP and overlap with the gut inhibitory activity of GLP-1.