Anti-PYY(3-36) (peptide tyrosine-tyrosine amide, 3-36)

ABS 051-04

ABS 051-04 binds human PYY(3-36). Based on inhibition ELISA, ABS 051-04 shows no cross-reaction with PYY(1-36) or NPY.

Synthetic N-terminal fragment of human PYY(3-36) coupled to carrier.

Mouse

Human

Mouse, Rat, Dog, Pig

IgG2a/k

5697

4

The epitope lies within residues 3-12 of human PYY.

400 µL: Cat. No. ABS 051-04-04 1 mL: Cat. No. ABS 051-04-1 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Protein A/G purified (from culture supernatant)

Liquid

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Unconjugated BSA free

4-8ºC without exposure to light. No precautions necessary during handling.

Peptide tyrosine-tyrosine amide (3-36), or PYY(3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY(3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY(3-36) is additive to that of the co-secreted gut hormone GLP-1.