| Specificity |
ABS 052-121 binds human ghrelin. |
| Immunogen |
Synthetic ghrelin (14-28) |
| Target |
Ghrelin is an orexigenic (food intake stimulating) 27 or 28 amino-acid gut-brain peptide hormone produced by endocrine cells in the stomach, pancreatic islets and certain hypothalamic neurons. Two forms are produced by alternative mRNA splicing; Gln13 or 14 is missing from the second form. "Active" ghrelin is acylated (octanoylated) at Ser3; this form stimulates growth hormone secretion via GHS receptors and increases appetite. The des-acyl form does not have these effects but may have other actions. Plasma responses of total ghrelin to food reflect those of active ghrelin. |
| Gene ID |
51738, 59301 |
| Species Reactivity POSITIVE |
Human, Rat, Mouse, Dog, Cat |
| Species Reactivity NEGATIVE |
Not determined |
